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Crispin’s background is transmission electron microscopy in materials science. In his various job positions in microscope user facilities, he gained a wide experience of different samples and of microscopy techniques including high resolution and aberration correction in TEM and STEM. His present role in nCHREM now mainly involves operation and maintenance of the Lund JEOL CryoTEM and preparation of samples in the Leica EM grid plunge-freezer. Regular samples include vesicles and fibres, but single particle work – preparation and screening – is becoming important too.
Contact: crispin [dot] hetherington [at] chem [dot] lu [dot] se
All animals and some bacteria can synthesize linear polysaccharides with a backbone of repeating disaccharide units, called glycosaminoglycans (GAGs). One of the most common types of GAGs is chondroitin/dermatan sulfate (CS/DS), which can bind cytokines and growth factors and is directly involved in receptor interactions. For example, the presence and structure of CS/DS is important for migration and invasion of cancer cells, development of atherosclerosis, neuronal outgrowth, and malaria infection. Emil's research is focused on understanding the structural and mechanistic aspects of the CS/DS biosynthesis, in order to aid the design and development of novel treatment therapies. For structural biology studies, he has mainly worked with x-ray crystallography and cryo-EM SPA.
emil [dot] tykesson [at] med [dot] lu [dot] se